Publications
The cross-disciplinary know-how, involving both experimental and computational approaches, as well as the range of services provided by CBS to its clients, are exemplified in the following list of publications by CBS authors.
| Publication | Type of work | Service |
|---|---|---|
| On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. Proc. Natl. Acad. Sci. USA, 101, 16774-16779. Abstract | Computational | Model Set Up (small scale) |
| Decrease of plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae. J. Biol. Chem. 279, 6501-6506. Abstract | Experimental | Experimental Design |
| Voltage-dependent anion channels control the release of superoxide anion from mitochondria to cytosol. J. Biol. Chem. 278, 5557-5563. Abstract | Experimental | Analysis of Data |
| Decreased cellular permeability to H2O2 protects Saccharomyces cerevisiae cells in stationary phase against oxidative stress. FEBS Lett., 578, 152-156. Abstract | Experimental | Analysis of Data |
| Diagnosis of enzyme inhibition based on the degree of inhibition. Biochim. Biophys. Acta - General Subjects 1624, 11-20. Abstract | Experimental/ Computational | Enzyme Kinetics |
| Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis. Eur. J. Biochem. 270, 3778-3886. Abstract | Experimental | Analysis of Data |
| Mitochondrial damage by NO is potentiated by dopamine in PC12 cells. Biochim. Biophys. Acta - Bioenergetics. 1556, 233-238. Abstract | Experimental/ Computational | Analysis of Data |
| Relative contributions of heart mitochondria glutathione peroxidase and catalase to H2O2 detoxification in in vivo conditions. Free Radic. Biol. Med., 33, 1260-1267. Abstract | Experimental/ Computational | Analysis of Data and Experimental Design |
| Determination of alpha-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein. Chem. Res. Toxicol. 15, 870-876. Abstract | Experimental/ Computational | Analysis of Data and Experimental Design |
| Apoptosis induced by exposure to a low and steady state concentration of H2O2 is a consequence of lysosomal rupture. Biochem. J., 356, 549-555. Abstract | Experimental | Experimental Design |
| Cellular titration of apoptosis with steady-state concentrations of H2O2. Sub-micromolar levels of H2O2 induce apoptosis through Fenton chemistry independent of the cellular thiol state. Free Radic. Biol. Med., 30, 1008-1018. Abstract | Experimental | Experimental Design |
| Estimation of H2O2 gradients across biomembranes. FEBS Lett., 475, 121-126. Abstract | Experimental/ Computational | Model Set Up (small scale) and Experimental Design |
| Determination of propagation and of termination rate constants by using an extension to the rotating-sector method: application to PLPC and DLPC bilayers. Int. J. Chem. Kinetics, 30, 753-767. Abstract | Experimental/ Computational | Model Set Up (small scale) and Experimental Design |
| Antioxidant activity of vitamin E determined in a phospholipid membrane by product studies: avoiding chain-transfer reactions by vitamin E radicals. J. Am. Chem. Soc., 119, 5764-5765. Abstract | Experimental | Experimental Design |
| Role of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in the reduction of lysophosholipid hydroperoxides. Free Radic. Biol. Med., 22, 871-883. Abstract | Experimental/ Computational | Model Set Up (large scale) and Analysis of Data |
| Lipid peroxidation in mitochondrial inner membranes: I. An integrative model. Free Radic. Biol. Med., 21, 917-943. Abstract | Computational | Model Set Up (large scale) |
| PHGPx and phospholipase A2/GPx: comparative importance on the reduction of hydroperoxides in rat liver mitochondria. Free Radic. Biol. Med., 19, 669-677. Abstract | Computational | Model Set Up (large scale) |
| Kinetic modelling of in vitro lipid peroxidation experiments "Low level" validation of a model of in vivo lipid peroxidation. Free Radic. Res., 23, 151-172. Abstract | Computational | Model Set Up (large scale) |